Although TRIM22 depletion did not significantly change the levels of euchromatin marks on ICP27 and ICP4 promoters, there was a trend towards increased density of H3K9Ac immunoprecipitated on the ICP27 promoter in 7134 and 7134R virus infection under conditions of TRIM22 depletion (S7 Fig). Here, TRIM22 is linked to viral infectious disease.