In addition, TRIM22 depletion reduced the density of H3K9me3 and H3K27me3 immunoprecipitated on the ICP27 and ICP4 promoters in the 7134 virus infection, indicating that the viral DNA is not silenced to the same extent in TRIM22-depleted fibroblasts (Fig 5B and 5C). The gene discussed is TRIM22; the disease is viral infectious disease.