A significant Multiple of Median (MoM) deviation in Ut-PI (19%), PAPP-A (31%), and PGLF (24%) was observed in high-risk groups with a history of PE and high-risk group with a history of hypertension, only PAPP-A (49%) and PLGF (30%) reported having a significant MoM deviation to the control group. The gene discussed is PGF; the disease is Hypertension.