PAPPA and preeclampsia: Assessment of Fetal specific marker hypermethylated RASSF1A gene to quantify cffDNA and its relationship with placental protein-13 (pp-13), PAPP-A and urine proteins in diagnosed pre-eclamptic cases show that the mean hypermethylated RASSF1A concentrations, pp-13, PAPP-A and maternal urine protein were significantly higher among the preeclampsia cases in each group of gestation as compared to controls (P < 0.001).