GLDC and cerebral malformation: As shown in Fig 5D, in mice at or below 60 days of age, we detected a 2.9-fold increase in plasma glycine levels in GldcATT/ATT compared to wild type littermates, For neurological disease, we reviewed the wide range of neurological symptoms and brain malformations associated with human NKH (Farris et al. 2020 and references within)[16].