Sirt1 is critical for heart embryo morphogenesis, knockout of Sirt1 in the embryonic stage will lead to a substantial rate of perinatal mortality associated with cardiac malformations, and interestingly, cardiac‐specific knockout of Sirt1 in adult mice shows no obvious phenotypes at basal conditions, but these mice will be more susceptible to cell death under stress conditions,27, 41, 42 indicating that Sirt1 is involved in the pathogenesis of cardiovascular diseases. Here, SIRT1 is linked to cardiovascular disorder.