Our previous study showed that EIF4G1 combined with USP10 in the lung cancer cell line A549, as determined by co‐immunoprecipitation analysis, so we assume that EIF4G1 can inhibit the USP10‐mediated stabilization of p53 by binding to USP10, leading to the inhibition of p53 functions in cancer cells. The gene discussed is USP10; the disease is lung carcinoma.