We confirmed the prognostic role of the dECIF variable after adjustment for age at diagnosis (adjusted HR = 3.45; 95% CI: 1.61–7.39), tumor size (adjusted HR = 3.24; 95% CI: 1.52–6.87), ER status (adjusted HR = 3.19; 95% CI: 1.51–6.71), PgR status (adjusted HR = 3.40; 95% CI: 1.57–7.38), and PAM50 predictor (adjusted HR = 3.74; 95% CI: 1.71–8.15). Here, ESR1 is linked to neoplasm.