KLF5 and renal fibrosis: Li et al subjected male C57BL/6 mice to 5/6 nephrectomy, which demonstrated significantly increased renal fibrosis and renal dysfunction (increased ACR and BUN) at 12 weeks after operation, along with significant increase in renal expression of KLF5, predominantly in the renal tubular cells as detected by immunofluorescent staining and Western blotting.11