Moreover, studies have shown that Gpx‐1 deficient mice have enhanced pulmonary inflammation (Duong et al., 2010), as well as worsened cardiovascular outcomes including a larger infarct volume following ischaemic stroke (Crack et al., 2001; Duong et al., 2010), suggesting that Gpx‐1 (or compounds which mimic its actions, such as ebselen) may exhibit protective effects. This evidence concerns the gene GPX1 and ischemic stroke.