This network meta-analysis (NMA) systematically evaluated the efficacy and acceptability of S1P receptors, as disease-modifying drugs, in the treatment of patients with MS, so as to find out the most appropriate therapeutic strategy and provide a reliable basis for the prescription of S1P drugs for patients with MS.<h4>Methods</h4>We conducted a systematic review and NMA to compare the efficacy and acceptability of S1P receptors for treating MS patients. Here, MBTPS1 is linked to myeloid sarcoma.