As ROS seem to be not involved in the cytotoxic effect of GP on melanoma cells, the role of GP on mitochondria was studied because members of the Bcl-2 family interacting with GP have been described to play a crucial role in the maintenance of mitochondrial integrity and regulation of the intrinsic apoptotic pathway (Henz et al. 2019; Pena-Blanco and Garcia-Saez 2018). Here, BCL2 is linked to melanoma.