Tamsulosin is also commonly prescribed for the same indication as TZ/DZ/AZ, benign prostatic hyperplasia, and crosses the blood-brain barrier24 but lacks the interaction with PGK1 that enhances glycolysis,22 providing a unique opportunity to use tamsulosin as a control in testing whether TZ/DZ/AZ benefits people with PD. The gene discussed is PGK1; the disease is Parkinson disease.