Tamsulosin is also commonly prescribed for the same indication as TZ/DZ/AZ, benign prostatic hyperplasia, and crosses the blood-brain barrier24 but lacks the interaction with PGK1 that enhances glycolysis,22 providing a unique opportunity to use tamsulosin as a control in testing whether TZ/DZ/AZ benefits people with PD. Here, PGK1 is linked to benign prostatic hyperplasia.