PGK1 and hypertensive disorder: TZ is an α1-adrenergic receptor antagonist that is commonly used to manage benign prostatic hyperplasia and, rarely, hypertension.23 The effects of TZ on PGK1 are independent of effects on α1-adrenergic receptors.21 Two other closely related α1-adrenergic antagonists, doxazosin (DZ) and alfuzosin (AZ), have a similar PGK1 binding motif, enhance energy metabolism, and are efficacious in a PD model.22 Tamsulosin is another α1-adrenergic receptor antagonist.