PGK1 and Parkinson disease: An opportunity to test this idea came when biochemical, functional, and structural studies showed that terazosin (TZ) binds and increases the activity of phosphoglycerate kinase 1 (PGK1), the first ATP-generating enzyme in glycolysis.21 TZ crosses the blood-brain barrier, increasing glycolysis and ATP in brain cells.22 Studies in toxin-induced and genetic models of PD in mice, rats, flies, and cells revealed that TZ slowed or prevented neuron loss.22