miR-16 expression was reported to be upregulated by epigallocatechin gallate (one of the polyphenols in green tea having anti-tumorigenesis effect) in 4 T1 murine breast cancer (BC) cells and involved in repolarization of M1 macrophages by regulating the TAMs in the TME through reduction of IL-6 and TGF-β and high TNFα [39]. This evidence concerns the gene TNF and breast cancer.