Another example is ORC6 in which the N-terminus harbors a structured TFIIB domain, but we noticed sgRNA depletions in the remaining regions, especially the C-terminal extremity, which is a septin-binding-region essential for cytokinesis and mutations in a conserved C-terminal motif have also been linked to Meier-Gorlin Syndrome (Akhmetova et al., 2015; Balasov et al., 2020; Balasov et al., 2015; Balasov et al., 2007; Bicknell et al., 2011a; Prasanth et al., 2002; Xu et al., 2020). This evidence concerns the gene ORC6 and Meier-Gorlin syndrome.