ORC6 and Meier-Gorlin syndrome: In humans, mutations in ORC1, ORC4, ORC6, CDT1, and CDC6 are detected in Meier-Gorlin syndrome (MGS) patients (Bicknell et al., 2011b; Bicknell et al., 2011a; Guernsey et al., 2011; Hossain and Stillman, 2012; de Munnik et al., 2015).