Interestingly, NEAT1 expression is elevated in 1-Methyl-4-phenyl-2, 3, 6-tetrahydropyridine (MPTP)-induced PD mice, and its knockdown can reduce the ratio of Bax to Bcl-2, the activity of caspase-3 and α-synuclein expression in neurons to exert ameliorative effects [12]. The gene discussed is NEAT1; the disease is Parkinson disease.