PDGF‐D can also be used for AD‐MSCs preconditioning before transplantation because it increases their proliferation and migration; upregulates expression of growth factors (such as VEGFA, FGF1, FGF5, bone morphogenetic protein 8B [BMP8B], leukemia inhibitory factor [LIF], inhibin beta A [INHBA], IL11, and heparin‐binding EGF‐like growth factor [HBEGF]) in AD‐MSCs and enhances their regenerative potential.245. This evidence concerns the gene FGF5 and Alzheimer disease.