AD‐MSCs from obese individuals have upregulated adipogenic and inflammatory genes, enhanced epithelial‐mesenchymal transition, reduced expression of multipotency‐associated genes (e.g., OCT4, SAL4, SOX15, and KLF4), and decreased telomerase activity and telomere length (self‐renewal capacity). This evidence concerns the gene POU5F1 and Alzheimer disease.