RBPJ and myocardial infarction: Knocking out RBP-J to partially inhibit Notch signaling is revealed to be responsible for aggravating myocardial cell apoptosis and impairing heart remodeling ability after myocardial infarction (MI) in murine hearts, indicating that Notch signaling has a protective effect on cardiomyocyte apoptosis after cardiac injury (He et al. 2018).