These genomic characterizations have shown that mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes play a pivotal role in gliomagenesis, with a significant clinical and prognostic impact.2IDH-mutant gliomas are sub-divided into oligodendroglial and astrocytic types by the status of loss of chromosomes 1p and 19q, with the former presenting with distinctive morphology and better prognosis. The gene discussed is IDH1; the disease is central nervous system cancer.