In this article, considering the relevant importance of IDH both in lower-grade gliomas and glioblastoma, 1p/19q in IDH-mutant lower-grade gliomas, and EGFRvIII in glioblastoma, we developed radiogenomic markers of IDH, 1p/19q, and EGFRvIII in the respective histologic categories. The gene discussed is IDH2; the disease is central nervous system cancer.