IDH1 and glioma: These genomic characterizations have shown that mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) genes play a pivotal role in gliomagenesis, with a significant clinical and prognostic impact.2IDH-mutant gliomas are sub-divided into oligodendroglial and astrocytic types by the status of loss of chromosomes 1p and 19q, with the former presenting with distinctive morphology and better prognosis.