The JAK inhibitors fedratinib, filgotinib, and peficitinib have been shown to abrogate JAK/STAT signaling and induce anti-tumor effects in solid tumor cell lines, but, to date, there are no clinical trials investigating these agents in solid tumors; lestaurtinib has been tested clinically in solid tumors for its activity against other targets not directly involved in the JAK/STAT pathway. Here, SOAT1 is linked to neoplasm.