CD274 and polycystic ovary syndrome: Among them, the allele frequency of the rs7421861 and rs10204525 in the PD-1 gene SNP loci and the rs2282055, rs2890658, rs702275, and rs10125854 in the PD-L1 SNP loci gene had statistically significant differences between the PCOS group and the control group (Table 4, P < 0.05).