This showed that APOE was upregulated in a variety of tumours, including DLBC, oesophageal carcinoma (ESCA), GBM, head and neck squamous cell carcinoma (HNSC), LGG, liver hepatocellular carcinoma (LIHC), pancreatic adenocarcinoma (PAAD), prostate adenocarcinoma (PRAD), skin cutaneous melanoma (SKCM), stomach adenocarcinoma (STAD), testicular germ cell tumours (TGCTs), THCA, THYM, uterine corpus endometrial carcinoma (UCEC), and uterine carcinosarcoma (UC) (Figure 9(a)). This evidence concerns the gene APOE and cutaneous melanoma.