In summary, we developed and validated successfully a LASSO-derived prediction nomogram based on 10 routine clinical parameters conveniently including “sex,” age,” “hypertension,” “smoking habit,” “GGT,” “CRP,” “HDL-C,” “cholesterol,” “waist circumference,” and “follow-up period,” and demonstrated that it provides a good level of performance for predicting subclinical coronary atherosclerosis in subjects with baseline zero score. The gene discussed is CRP; the disease is hypertensive disorder.