RCC2 and neoplasm: Further, RCC2 is implicated in tumor cell proliferation (Matsuo et al., 2013; Chen et al., 2019; Yu et al., 2019), apoptosis and sensitivity (Wu et al., 2018; Gong et al., 2019; Yu et al., 2019), and poor prognosis of microsatellite stable (MSS) tumors (Bruun et al., 2015).