Specifically, these findings are in accordance with those from Chia's group (Chia et al., 2018), who observed CXCL12–CXCR4 (Sdf1b-Cxcr4b) signaling to mediate macrophage infiltration and differentiation into microglia in zebrafish larvae modeling early glioma through the neuronal expression of the human oncogene AKT. Here, CXCL12 is linked to central nervous system cancer.