TGFB1 and chronic obstructive pulmonary disease: Gu's research shows that taurine-upregulated gene 1 (TUG1) expression is enhanced in COPD patients, and TUG1 inhibits the expression of miR-145-5pp/DUSP6 axis to promote airway remodelings such as TGF-β1, mucus hypersecretion, collagen 1 and α-SMA and inflammation such as increased IL-6 and pulmonary neutrophil infiltration (67).