A large number of oncogenes as target genes of miR-505 in tumor cells, including TGF-α (Chen S. et al., 2016), HMGB1 (Lu et al., 2016; Liu et al., 2018; Tian et al., 2018), FZD4 (Ma et al., 2017), IGF1R (Shi et al., 2018), WNT7B (Zhang et al., 2018), MAP3K3 (Tang et al., 2019), NRCAM (Ling et al., 2019), and RUNX2 (Zhao et al., 2019), have been recognized as direct target genes of miR-505. The gene discussed is RUNX2; the disease is neoplasm.