Several recent studies, however, demonstrated that type1 IFN production is dependent on tumor cGAS to generate cGAMP, which can then be secreted as an immunotrasmitter that enter other cells such as DC/TAMs to stimulate STING and thereby type 1 IFN production (Marcus et al., 2018; Carozza et al., 2020; Zhou et al., 2020a). This evidence concerns the gene STING1 and neoplasm.