Previous studies have shown that TGs and DGs were increased in obesity and T2D (Bitzur et al., 2009; Erion and Shulman, 2010; Markgraf et al., 2016), and PC levels were reduced in obese or insulin-resistant subjects (Razquin et al., 2018). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.