Moreover, hsa_circ_0136666 is highly expressed in CRC and the silence of hsa_circ_0136666 regulates the proliferation and migration of colorectal cancer (CRC) cells by sponging miR-136, thus modulating the expression of SH2B adaptor protein 1 (SH2B1) (Jin et al., 2019). The gene discussed is SH2B1; the disease is colorectal carcinoma.