Similar to breast cancer, KL might be tumor-suppressing by inhibiting IGF-1R–dependent PI3K/AKT signaling (Li et al., 2014) or aerobic glycolysis via ERK/hypoxia-inducible factor 1α (HIF-1α) (Li et al., 2018) in CRC. This evidence concerns the gene IGF1R and colorectal carcinoma.