↓ Cell survival; proliferation↓ Tumor growth; weight; volume ↑ Cell cycle arrest ↑ Apoptosis⊣ IGF-1R/PI3K/AKT⊣ ERK and HIF-1α⊣ NF-κB⊣ Wnt3a/β-catenin signaling. Here, IGF1R is linked to neoplasm.