KL and neoplasm: KL overexpression or treatment with recombinant KL or sKL decreases colony formation, cell proliferation, migration, and tumor invasion while inducing apoptosis and autophagy through inhibition of Wnt/β-catenin (Sun et al., 2015; Tang et al., 2016b) and IGF-1R/AKT/ERK signaling (Shu et al., 2013).