HCC cells and HCC tissue exhibit reduced KL expression (Shu et al., 2013; Xie et al., 2013b; Sun et al., 2015; Tang et al., 2016b), a phenomenon again explained by epigenetic silencing of the KL promoter through hypermethylation and acetylation (Xie et al., 2013b). The gene discussed is KL; the disease is hepatocellular carcinoma.