Benign soft tissue (mesenchymal) tumors are most frequently responsible for TIO (Boland et al., 2018), but also malignancies including colon adenocarcinoma (Leaf et al., 2013), ovarian cancer (Lin et al., 2014), small cell carcinoma of the lung (Sauder et al., 2016), anaplastic thyroid carcinoma (Abate et al., 2016), B-cell non-Hodgkin lymphoma (Elderman et al., 2016), breast cancer (Savva et al., 2019), and intracranial tumors (Colazo et al., 2020) can produce FGF23. This evidence concerns the gene FGF23 and ovarian carcinoma.