Independently of kidney disease, FGF23 is associated with carotid atherosclerosis (Rodríguez-Ortiz et al., 2020), fibrosis, and poorer prognosis in heart failure (Roy et al., 2020) and prognosis in heart failure with preserved ejection fraction (Kanagala et al., 2020). The gene discussed is FGF23; the disease is heart failure.