KL and colorectal cancer: Also, in human colorectal cancer (CRC) specimens, KL promoter methylation with reduced KL mRNA is frequent (Gan et al., 2011; Pan et al., 2011; Li et al., 2014; Yang et al., 2014; Perveez et al., 2015; Arbel Rubinstein et al., 2019; Liu et al., 2019; Son et al., 2020).