KL inhibits lung cancer cell proliferation, growth, invasiveness, and migration and fosters apoptosis (Chen et al., 2010, 2012, 2016, 2019; Wang X. et al., 2011; Wang et al., 2013), effects, at least in part, dependent on IGF-1R/AKT (Chen et al., 2010; Wang et al., 2013) and Wnt3a/β-catenin signaling (Chen et al., 2012, 2019) and on reduced interleukin 6 (IL-6) and IL-8 production (Chen B. et al., 2018). This evidence concerns the gene AKT1 and lung cancer.