Mutations in the NTNG1 gene are linked to Rett syndrome with epileptic seizures of early onset (Archer et al., 2006; Nectoux et al., 2007), and a more recent study revealed that netrin G2 dysfunction is associated with a Rett-like phenotype with areflexia (Heimer et al., 2020). This evidence concerns the gene NTNG1 and atypical Rett syndrome.