Interestingly, studies carried out on AMD highlighted that Dicer1 mRNA was reduced in the RPE, but not into neural retina, by 65 ± 3% compared to control eyes, while there was no differences in Drosha and Dgcr8 mRNAs in AMD eyes (Kaneko et al., 2011). The gene discussed is DGCR8; the disease is age-related macular degeneration.