Although MICAL-1, another member of the MICAL family, was reported to exert its effect on breast cancer cell proliferation via ROS-sensitive PI3K/AKT/ERK signaling (Deng et al., 2018), the function of MICAL-L2 in NSCLC cell proliferation and progression is largely unknown. Here, MICAL1 is linked to non-small cell lung carcinoma.