Moreover, reduced IL-6 and IL-1b, two relevant inflammatory cytokines in sepsis that it have been reported to play a relevant role in COVID-19 [as highlighted by the different clinical trials using different monoclonal antibodies targeting IL-6 (Tocilizumab) (De Luna et al., 2020; Toniati et al., 2020) as well as IL-1b (Anakinra) (Huet et al., 2020)], was also observed (Wilson et al., 2015; McIntyre et al., 2018). This evidence concerns the gene IL1B and COVID-19.