Several miRNAs are reported to regulate the expression of FOXO3 in various cell types via directly binding to 3’-UTR, such as miR-155 in liver cancer cells (Liao et al., 2018), miR-10b-3p in esophageal squamous cell carcinoma cells (Lu et al., 2018), and miR-34a in macrophages (Song et al., 2017). This evidence concerns the gene FOXO3 and liver cancer.