Genistein also displays down-regulation of all MMP genes (MMP-1,−2,−3,−7,−9,−11,−14,−15,−16) along with up-regulation of TIMP-1 level while TIMP-2 level is being suppressed in MDA-MB-231 and MCF-7 cancer cell lines (Kousidou et al., 2005; Lee W. Y. et al., 2007). The gene discussed is MMP1; the disease is cancer.