Although OM-sIgE levels at <2 years of age and the peak egg white IgE levels >50 UA/ml in the low-dose HE reactor group were significantly higher than that in the HE tolerance group, multivariate logistic regression analysis revealed that avoidance of HE was associated with low-dose HE reactor even after adjusting the OM-sIgE levels at <2 years of age or the peak egg white IgE levels >50 UA/ml, respectively (adjusted odds ratio (aOR) = 14.5; 95% confidence interval (CI): 1.63–128.7, aOR = 10.8; 95%CI: 1.16–99.4, respectively, see Table 2). The gene discussed is IGHE; the disease is hereditary elliptocytosis.