With regard to the genetic factors involved, a single-nucleotide polymorphism occurring in the sequence of the human patatin-like phospholipase domain-containing 3 gene (PNPLA3), known as I148M variant, is one of the most investigated variants as it is associated with increased of developing hepatic steatosis and progressing to advanced fibrosis [3]. Here, PNPLA3 is linked to fatty liver disease.