As described above, C. trachomatis RBs enter the persister state when exposed to different conditions, such as treatment with IFN-γ or antibiotics including penicillin (Panzetta et al., 2018), azithromycin (Xue et al., 2017), and erythromycin (Clark et al., 1982), by amino acid starvation (Wyrick, 2010), or co-infection with Herpes viruses (Deka et al., 2006; Prusty et al., 2012). The gene discussed is IFNG; the disease is coinfection.