Under special conditions, such as treatment with interferon-gamma (IFN-γ) or penicillin, nutrient deprivation, or co-infection with Herpes viruses (Deka et al., 2006), RBs convert into persistent, nonreplicative particles, termed aberrant reticulate bodies (ARBs), which may re-convert into RBs and infectious EBs when the unfavorable conditions subside (Elwell et al., 2016; Witkin et al., 2017; Xue et al., 2017; Panzetta et al., 2018). Here, IFNG is linked to coinfection.