HMGB1 and infection: Proinflammatory cytokines and molecules related to Th1 cells (TNF-α, IL-8, IFN-γ, IL-1β, TREM1, and PTGS2) were upregulated in the pathways HMGB1 Signaling, Neuroinflammation Signaling Pathway, TREM1 Signaling, Type I Diabetes Mellitus Signaling, MIF-mediated Glucocorticoid Regulation, and Dendritic Cell Maturation after 6, 12, and 24 h post infection.