The pathways related to the Th1 response (HMGB1 Signaling, Neuroinflammation Signaling pathway, TREM1 Signaling, MIF-mediated Glucocorticoid Regulation, Dendritic Cell Maturation, and Type I Diabetes Mellitus Signaling) were activated at 6, 12 and 24 h after M. avium infection. The gene discussed is TREM1; the disease is type 1 diabetes mellitus.