In addition, Th17 immune response-related pathways (LXR/RXR Activation, Role of Macrophages, Fibroblasts ad Endothelial Cells in Rheumatoid Arthritis, IL-6 Signaling, STAT3 Signaling, LPS/IL-1 Mediated Inhibition of RXR Function, and PPAR Signaling) were also activated (Supplementary Table 2). This evidence concerns the gene IL1B and rheumatoid arthritis.