Further research showed that SATB2-AS1 could directly bind to WDR5 (WD repeat domain 5) and GADD45A (growth arrest and DNA damage-inducible alpha), and then activate SATB2 transcription by mediating the tri-methylation of lysine 4 on histone 3 (H3K4me3) and the DNA demethylation of the promoter region of SATB2, thus inhibiting the migration, invasion, and metastasis of CRC (18). The gene discussed is GADD45A; the disease is colorectal carcinoma.