HOTAIR and gastric cancer: For example, in gastric cancer, HOTAIR, functioning as a connecting scaffold, could facilitate the ubiquitination and degradation of Runx3 (runt-related transcription factor 3) by enhancing the interaction between E3 ubiquitin ligase Mex3b (mex-3 RNA binding family member B) and Runx3, thus inhibiting the expression of E-cadherin and Claudin1, and ultimately promoting the migration and invasion of gastric cancer (80).