found that the expression levels of plakoglobin and desmoglein 2 (both are involved in maintaining intercellular adhesion) in squamous carcinoma cells derived from the top of the oral cavity are significantly lower than those in squamous carcinoma cells derived from the tongue, which is helpful for the migration and invasion of cells, and may be used to explain why the metastasis rate of OSCC in the soft palate is higher than that in the tongue (9). This evidence concerns the gene DSG2 and squamous cell carcinoma.