JAK2 and myelodysplastic syndrome: In our study, we found JAK2-mutated patients had lower ANC (<0.8×10^9/L, 76.19 vs. 29.72%, p < 0.0001) than JAK2 wildtype patients and tended to be more responsible for MF (19.05% vs. 6.13%, p=0.0129) which further confirmed JAK2 mutations reinforced the pathogenesis of MDS, may be involved in disease progression in LR-MDS.