Multivariable survival analysis revealed JAK2 [HR 6.58, 95%CI 2.72–15.91, p < 0.0001] and RUNX1 [HR 3.25, 95%CI 1.19–8.89, p = 0.0215] mutations were independently prognostic for PFS in LR-MDS. This evidence concerns the gene JAK2 and myelodysplastic syndrome.