NFKB1 and neoplasm: Inflammation triggered by microorganisms is beneficial in defending against pathogens; however, if inflammation persists, it may lead to tissue fibrosis and even carcinogenesis, Microbial-induced inflammation leads to tumor development by activating tumor-related inflammatory signaling pathways, including proinflammatory cytokines, Toll-like receptor (TLR)/MyD88 (myeloid differentiation primary response gene 88) pathway, nuclear factor-kappa B (NF-κB), etc., constitute a fine and complex network (70–72).