Although the interaction of Ppm1b with p-RIP3 in MDA-MB-231 cells (Figures 4A–C) explains the role of Ppm1b in preventing necroptosis in breast cancer cells and in vivo (Figures 5A, B), the mechanism of Ppm1b during necroptosis is still unclear. The gene discussed is PPM1B; the disease is breast carcinoma.