PPM1B and breast carcinoma: In this study, we report the cell death forms induced by 3-BP, we found that 3-BP, a glycolysis inhibitor can induce cell death in breast cancer cells, MDA-MB-231 and MCF-7, respectively, especially in MDA-MB-231 cells by regulating Ppm1b and necroptosis, which are crucial for our understanding of breast cancer cell death signaling network.