ZBTB7A acts as a tumor suppressor in RUNX1-RUNX1T1 AML, so the specific association of ZBTB7A’s loss-of-function-mutations with t (8;21) rearranged AML can point towards leukemogenic cooperativity between mutant ZBTB7A and the RUNX1/RUNX1T1 fusion (71). The gene discussed is RUNX1T1; the disease is acute myeloid leukemia.