And, we showed that PLAU expression might be an independent prognosis index for HNSCC patients, which consistent with many other cancer reports (Mahmood, Mihalcioiu & Rabbani, 2018) including breast cancer, prostate cancer, ovarian cancer, sarcoma, melanoma, gastric cancer, esophageal cancer, and colorectal cancer. Here, PLAU is linked to colorectal cancer.