In addition, global miRNA expression profiling suggested mTOR controls many miRNAs expression in chronic rapamycin (RAP, a specific TOR inhibitor produced by Streptomyces hygroscopicus) treatment of cancer cells and the mouse and human cells with inactivation of TSC complex (an essential repressor of mTOR activation) (Ye et al., 2015; Totary-Jain et al., 2013; Jewell, Flores & Guan, 2015). The gene discussed is MTOR; the disease is cancer.