The top 10 significant pathways were represented, including ECM-receptor interaction, PI3K-Akt signaling pathway, Hippo signaling pathway, complement and coagulation cascades, TGF-beta signaling pathway, MAPK signaling pathway, proteoglycans in cancer, protein digestion, focal adhesion, and cell adhesion molecules (Fig. 3). This evidence concerns the gene AKT1 and cancer.