BACE2 and neoplasm: Table 3 shows the determinants of BACE2, ING2 ALOX5AP, HLA-DMB, HLA-DRA, and SPINT2 for all the patients. In the univariate analysis, These gene signatures exhibited a negative correlation with age, gender, specific and primary tumor site, but illustrate a positive correlation with recurrence and risk score. After multiple stepwise analysis, these biomarkers correlated independently with Recurrence (hazard ratio (HR) 5.374, 95% CI [1.183–24.404], p = 0.029) and risk score (HR 9.869, 95% CI [4.663–20.887], p < 0.001).