ALOX5AP and osteosarcoma: Savage et al. (2013) suggested that two loci in the GRM4 gene at 6p21.3 and in the gene, desert, at 2p25.2, These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.The study addressed a single gene and did not take into account interactions among molecules that regulate tumorigenesis. Three candidate genes (ALOX5AP, CD74 and FCGR2A) were found. Their expression levels in lung and lymph nodes were higher than levels in matched cancer tissues, and they may be expressed in microenvironments (Li et al., 2020).