In the present study, we found a significantly higher leukocyte mRNA expression of both HIF1A and its target genes, including glucose transporter SLC2A1 and the rate limiting glycolytic enzymes such as PFK, PKM2, and LDHA in the patients with GDM compared to the subjects with NGT, suggesting a transcriptional up-regulation of the glycolytic phenotype in leukocytes of the diabetic patients. The gene discussed is HIF1A; the disease is gestational diabetes.