Our results reported (i) the linkage of WWOX/HIF1A-driven transcriptional regulation of the glycolytic phenotype in leukocytes of GDM patients, (ii) a significant correlation between glycemic control and leukocyte gene expression of HIF1A and WWOX modulated expression of its target genes HK2, PFK, and SLC2A1 that are involved in glycolysis, (iii) an important contribution of the WWOX gene to the pathogenesis of GDM by modulation HIF1α activity (Fig. 7). This evidence concerns the gene HK2 and gestational diabetes.