PKM and gestational diabetes: Further, we observed that NFKB1 expression correlated inversely with the expression WWOX and SLC2A4 as well as the WWOX/HIF1A ratio and positively with the expression of HIF-1α-responsive genes such as PKM2 and LDHA in the GDM women, clearly pointing to a crosstalk between NFKB1 upregulation, WWOX downregulation, impaired GLUT4-mediated intracellular transport of glucose, and enhanced glycolytic pathway in the condition of diabetic pregnancy; however, whether these associations have functional relevance for the development of GDM remains to be determined.