INS and Insulin resistance: What is more, HIF1α protein was shown increased in visceral adipose tissue (VAT) from the high fat diet mouse model and in VAT obtained from obese patients compared to those of normal-weight controls (Arcidiacono et al., 2020), and then hypoxia in obese adipose tissue may play a critical role in the impairment of peripheral insulin action and development of systemic insulin resistance.