TNF and rheumatoid arthritis: The biological processes of the upregulated 115 genes were enriched mainly in the TNF signaling pathway (2.83 × 10–5), NF-κB signaling pathway (6.02 × 10–3), influenza A (1.52 × 10–2) and rheumatoid arthritis (3.77 × 10–2) (Fig. 3A).